IITZ-01
CAS No. 1807988-47-1
IITZ-01 ( Autophagy inhibitor IITZ-01 )
Catalog No. M12762 CAS No. 1807988-47-1
IITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
Size | Price / USD | Stock | Quantity |
2MG | 30 | In Stock |
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5MG | 50 | In Stock |
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10MG | 87 | In Stock |
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25MG | 177 | In Stock |
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50MG | 312 | In Stock |
|
100MG | 483 | In Stock |
|
200MG | Get Quote | In Stock |
|
500MG | Get Quote | In Stock |
|
1G | Get Quote | In Stock |
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Biological Information
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Product NameIITZ-01
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NoteResearch use only, not for human use.
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Brief DescriptionIITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor.
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DescriptionIITZ-01 (Autophagy inhibitor IITZ-01) is a novel potent lysosomotropic autophagy inhibitor, exhibits >10-fold potent autophagy inhibition along with 12- to 20-fold better cytotoxic action than Chloroquine; enhances autophagosome accumulation but inhibit autophagosomal degradation by impairing lysosomal function, finally resulting in the inhibition of autophagy, also abolishes mitochondrial membrane potential and triggers apoptosis through the mitochondria-mediated pathway (TNBC cells IC50=1.54 uM, 48 h); displays potent antitumor action in vivo through autophagy inhibition and apoptosis induction in MDA-MB-231 breast cancer xenograft model.
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SynonymsAutophagy inhibitor IITZ-01
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research Area——
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Indication——
Chemical Information
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CAS Number1807988-47-1
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Formula Weight482.52
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Molecular FormulaC26H23FN8O
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Purity>98% (HPLC)
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SolubilityDMSO : 150 mg/mL 310.87 mM; H2O : < 0.1 mg/mL
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SMILESFC1=CC=C(NC2=NC(N3CCOCC3)=NC(NC4=CC=C(C5=NC6=CC=CC=C6N5)C=C4)=N2)C=C1
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Chemical NameN2-(4-(1H-benzo[d]imidazol-2-yl)phenyl)-N4-(4-fluorophenyl)-6-morpholino-1,3,5-triazine-2,4-diamine
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Guntuku L, et al. Oncogene. 2018 Aug 30. doi: 10.1038/s41388-018-0446-2.
molnova catalog
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