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SMER-28

CAS No. 307538-42-7

SMER-28 ( SMER28 )

Catalog No. M13983 CAS No. 307538-42-7

A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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25MG 116 In Stock
50MG 222 In Stock
100MG 428 In Stock
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Biological Information

  • Product Name
    SMER-28
  • Note
    Research use only, not for human use.
  • Brief Description
    A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF.
  • Description
    A small-molecule enhancer/inducer of Autophagy; decreases the levels of Aβ peptide (EC50=10 uM) and APP-CTF (EC50 of 20 uM) in a γ-secretase-independent manner in primary neuronal cultures, Atg5, Beclin1 and Ulk1 are shown to be involved in the degradation of Aβ and APP-CTF; enhances erythropoiesis in a range of in vitro and in vivo models of DBA, and protects against neurodegeneration in Drosophila model of Huntington’s disease.
  • Synonyms
    SMER28
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    Neurological Disease
  • Indication
    ——

Chemical Information

  • CAS Number
    307538-42-7
  • Formula Weight
    264.12
  • Molecular Formula
    C11H10BrN3
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 32 mg/mL
  • SMILES
    C=CCNC1=C2C=C(Br)C=CC2=NC=N1
  • Chemical Name
    4-Quinazolinamine, 6-bromo-N-2-propen-1-yl-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Doulatov S, et al. Sci Transl Med. 2017 Feb 8;9(376). pii: eaah5645.
2. Rosenthal AK, et al. J Biol Chem. 2015 May 22;290(21):13028-38.
3. Sarkar S, et al. Nat Chem Biol. 2007 Jun;3(6):331-8.
4. Tian Y et al. FASEB J. 2011 Jun;25(6):1934-42.
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