Cart
sales@molnova.com
Home - Products - GPCR/G Protein - Hedgehog (Hh) - SMO-IN-2

SMO-IN-2

CAS No. 1822355-27-0

SMO-IN-2( —— )

Catalog No. M35720 CAS No. 1822355-27-0

SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 240 Get Quote
5MG 359 Get Quote
10MG 541 Get Quote
25MG 854 Get Quote
50MG 1150 Get Quote
100MG 1512 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SMO-IN-2
  • Note
    Research use only, not for human use.
  • Brief Description
    SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.
  • Description
    SMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.
  • In Vitro
    SMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    GPCR/G Protein
  • Target
    Hedgehog (Hh)
  • Recptor
    Hedgehog/Smoothened
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1822355-27-0
  • Formula Weight
    503.49
  • Molecular Formula
    C25H25F4N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    N(C1=C(C(=O)N2CCC(N(C(=O)C3=C(C(F)(F)F)C=C(F)C=C3)C)CC2)C=CC=C1)C=4N(C)N=CC4
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • Hh-Ag1.5

    Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo.

  • RU-SKI 43

    A small molecule inhibitor of Hhat (Hedgehog acyltransferase) with IC50 of 0.85 uM.

  • HPI-1

    HPI-1 is a Hedgehog (Hh) pathway inhibitor that suppresses signaling through Shh (IC50=1.5 uM).

Sign In Join Free