Cart
sales@molnova.com
Smoothened Agonist (SAG)
CAS No. 912545-86-9
Smoothened Agonist (SAG)( Smoothened Agonist )
Catalog No. M16550 CAS No. 912545-86-9
SAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 80 | In Stock |
|
| 2MG | 53 | In Stock |
|
| 5MG | 79 | In Stock |
|
| 10MG | 117 | In Stock |
|
| 25MG | 234 | In Stock |
|
| 50MG | 315 | In Stock |
|
| 100MG | 468 | In Stock |
|
| 200MG | 668 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameSmoothened Agonist (SAG)
-
NoteResearch use only, not for human use.
-
Brief DescriptionSAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM).
-
DescriptionSAG is a potent Smoothened (Smo) receptor agonist (Kd = 59 nM); potently activates the Hedgehog signaling pathway in Shh-light 2 cells (EC50 ~ 3 nM).
-
In Vitro——
-
In VivoAnimal Model:Pregnant C57BL/6J mice Dosage:15, 17, 20 mg/kg Administration:A single i.p.Result:Effective in ca. 80% of the embryos and increased Gli1 and Gli2 mRNA expression in the limb bud, with Gli1 mRNA being the most upregulated at the dose of 20 mg/kg.
-
SynonymsSmoothened Agonist
-
PathwayGPCR/G Protein
-
TargetHedgehog (Hh)
-
RecptorSmoothened
-
Research AreaCancer
-
Indication——
Chemical Information
-
CAS Number912545-86-9
-
Formula Weight490.06
-
Molecular FormulaC28H28ClN3OS
-
Purity>98% (HPLC)
-
SolubilityEthanol: 40 mg/mL warmed (75.97 mM); Water: 100 mg/mL (189.92 mM); DMSO: 71 mg/mL warmed (134.84 mM)
-
SMILESCNC1CCC(CC1)N(CC1=CC=CC(=C1)C1=CC=NC=C1)C(=O)C1=C(Cl)C2=CC=CC=C2S1
-
Chemical Name——
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1.Chen JK, et al. Proc Natl Acad Sci U S A. 2002 Oct 29;99(22):14071-6.
molnova catalog
related products
-
Hh-Ag1.5
Hh-Ag1.5 (SAG-1.5) is a potent Hedgehog (Hh) agonist (EC50: 1 nM) and Smoothened (Smo) receptor agonist, with an EC50 of 1 nM and Ki values between 0.5 and 2.3 nM for Smo.
-
ALLO-2
ALLO-2 is a Inhibitor of Drug-Resistant Smo Mutant.It?inhibits Smo agonist Hh-Ag1.5-induced luciferase expression in TM3-Gli-Luc cells with IC50 of 6 nM.
-
SAG dihydrochloride
SAG dihydrochloride, a powerful agonist of the Smoothened (Smo) receptor (EC 50 = 3 nM; Kd = 59 nM), effectively activates the Hedgehog signaling pathway.
