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SMO-IN-2
CAS No. 1822355-27-0
SMO-IN-2( —— )
Catalog No. M35720 CAS No. 1822355-27-0
SMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 252 | In Stock |
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| 10MG | 378 | In Stock |
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| 25MG | 618 | In Stock |
|
| 50MG | 814 | In Stock |
|
| 100MG | 1088 | In Stock |
|
| 200MG | 1469 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSMO-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionSMO-IN-2 is a potent smoothened (SMO) inhibitor of hedgehog (Hh) signaling.SMO-IN-2 shows antiproliferative activity and anticancer activity against human medulloblastoma cell lines.SMO-IN-2 can be used in the study of cancer.
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DescriptionSMO-IN-2 (compound 1) is a potent smoothened (SMO) inhibitor with an IC50 value of 123.4 nM for hedgehog (Hh) signaling pathway. SMO-IN-2 has antiproliferative activity against human medulloblastoma cell line Daoy. Anticancer activity.
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In VitroSMO-IN-2 (compound 1) has antiproliferative activity against human medulloblastoma cell line Daoy with an IC50 of 0.51 μM.
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In Vivo——
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Synonyms——
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PathwayGPCR/G Protein
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TargetHedgehog (Hh)
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RecptorHedgehog/Smoothened
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Research Area——
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Indication——
Chemical Information
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CAS Number1822355-27-0
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Formula Weight503.49
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Molecular FormulaC25H25F4N5O2
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Purity>98% (HPLC)
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Solubility——
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SMILESN(C1=C(C(=O)N2CCC(N(C(=O)C3=C(C(F)(F)F)C=C(F)C=C3)C)CC2)C=CC=C1)C=4N(C)N=CC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Ji D, et al. Design, synthesis and biological evaluation of anthranilamide derivatives as potent SMO inhibitors. Bioorg Med Chem. 2020 Mar 15;28(6):115354.?
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