Cart
sales@molnova.com
Home - Products - Membrane Transporter/Ion Channel - TRP/TRPV Channel - SET 2

SET 2

CAS No. 2313525-20-9

SET 2( —— )

Catalog No. M34914 CAS No. 2313525-20-9

SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 50 Get Quote
10MG 84 Get Quote
25MG 172 Get Quote
50MG 291 Get Quote
100MG 415 Get Quote
500MG Get Quote Get Quote
1G Get Quote Get Quote
Get Quotation Bulk Inquiry Add to Cart

Biological Information

  • Product Name
    SET 2
  • Note
    Research use only, not for human use.
  • Brief Description
    SET 2 is an antagonist of transient receptor potential vanilloid type 2(TRPV2) with an IC50 of 0.46 μM. SET 2 shows selectivity over TRPV1, TRPV3 and TRPV4.
  • Description
    SET2 is a selective TRPV2 antagonist (IC50=0.46 μM). SET2 blocks the TRP channel and suppresses prostate cancer cells migration. SET2 reduces the lysophosphatidic acid (LPA, a TRPV2 activator)-induced cytoplasmic calcium increases.
  • In Vitro
    Cell Migration Assay Cell Line:PC-3M prostate cancer cells Concentration:0, 5 μM, 10 μM, and 20 μM Incubation Time:24 hr and 48 hr Result:Inhibited cell migration of PC-3M cells, without inhibiting cell viability at 48 hours.
  • In Vivo
    ——
  • Synonyms
    ——
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    TRP/TRPV Channel
  • Recptor
    TRP/TRPV Channel
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2313525-20-9
  • Formula Weight
    402.43
  • Molecular Formula
    C17H21F3N4O2S
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (248.49 mM; Ultrasonic (<60°C)
  • SMILES
    CCCN(C)c1cc(nc(SCCC(=O)NCc2ccco2)n1)C(F)(F)F
  • Chemical Name
    ——

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Chai H, et al. Structure-Based Discovery of a Subtype-Selective Inhibitor Targeting a Transient Receptor Potential Vanilloid Channel. J Med Chem. 2019 Feb 14;62(3):1373-1384. ?
Calculator

Molecular Weight Calculator

Dilution Calculator

Molarity Calculator

molnova catalog
related products

  • TRPA1-IN-2

    TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.

  • 9-Phenanthrol

    9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.

  • AMG-0347

    AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.

Sign In Join Free