9-Phenanthrol

Research use only, not for human use.

9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.

9-Phenanthrol is inhibitor of the transient receptor potential melastatin 4 (TRPM) channel, a Ca2+ -activated non-selective cation channel.(In Vitro):In addition, 9-phenanthrol, lacking the chemical groups necessary for CFTR activation, also reversibly inhibited TRPM4 with a similar IC(50). Channel inhibition was voltage independent. The IC(50) determined in the whole-cell and inside-out experiments were similar, suggesting a direct effect of the molecule. However, 9-phenanthrol was ineffective on TRPM5, the most closely related channel within the TRP protein family. We identify 9-phenanthrol as a TRPM4 inhibitor, without effects on TRPM5. It could be valuable in investigating the physiological functions of TRPM4, as distinct from those of TRPM5.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

HIF-1

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484-17-3

194.233

C14H10O

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (514.85 mM)

Oc1cc2ccccc2c2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years