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TRPA1-IN-2
CAS No. 2415206-22-1
TRPA1-IN-2( —— )
Catalog No. M36925 CAS No. 2415206-22-1
TRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 145 | In Stock |
|
| 5MG | 131 | In Stock |
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| 10MG | 199 | In Stock |
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| 25MG | 337 | In Stock |
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| 50MG | 461 | In Stock |
|
| 100MG | 620 | In Stock |
|
| 200MG | 833 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameTRPA1-IN-2
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NoteResearch use only, not for human use.
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Brief DescriptionTRPA1-IN-2 is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM.TRPA1-IN-2 has anti-inflammatory activity.
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DescriptionTRPA1-IN-2 (compound 1) is a potent and orally active TRPA1 inhibitor with an IC50 value of 0.04 μM. TRPA1-IN-2 shows anti-inflammation activity.
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In Vitro——
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In VivoAnimal Model:16-18 g, female BABL/c mice Dosage:90 mg/kg Administration:I.p.; for 7 days Result:Reduced the total number of white blood cells and eosinophils in BALF.Animal Model:160-180 g, SD male rats (asthmatic rats)Dosage:30 mg/kg Administration:I.p.; for 7 days Result:Significantly Sexually reduced lung inflammation area and airway inflammation score in asthmatic rats.
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number2415206-22-1
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Formula Weight442.48
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Molecular FormulaC24H25F3N4O
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Purity>98% (HPLC)
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SolubilityIn Vitro:?DMSO : 100 mg/mL (226.00 mM; Ultrasonic )
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SMILESC(=O)(C1(NC2=CC=C(C#N)C=C2)CCCC1)N3CCN(CC3)C4=CC=C(C(F)(F)F)C=C4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. YunFeng Cheng, et al. Heteroaromatic acetamide derivative, and preparation and use thereof. WO2020244460A1.
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