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AMG-0347
CAS No. 946615-43-6
AMG-0347( —— )
Catalog No. M34498 CAS No. 946615-43-6
AMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 567 | In Stock |
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| 5MG | 553 | In Stock |
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| 10MG | 734 | In Stock |
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| 25MG | 1112 | In Stock |
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| 50MG | 1460 | In Stock |
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| 100MG | 1962 | In Stock |
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| 200MG | 2651 | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameAMG-0347
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NoteResearch use only, not for human use.
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Brief DescriptionAMG-0347 (UNII-CD7L9290QR) is a small molecule inhibitor targeting TRPA1(transient receptor potential ankyrin 1) ion channels, a receptor found in sensory neurons and involved in the detection of pain and environmental stimuli. AMG-0347 acts by blocking the function of TRPA1 and has analgesic effects.
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DescriptionAMG0347 is a transient receptor potential type V1 receptor antagonist. AMG0347 inhibits activation of the rat TRPV1 channel by heat (IC50 = 0.2 nm), protons (IC50= 0.8 nm), or capsaicin (IC50 = 0.7 nm).
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In Vitro——
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In Vivo——
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Synonyms——
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PathwayMembrane Transporter/Ion Channel
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TargetTRP/TRPV Channel
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RecptorTRP/TRPV Channel
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Research Area——
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Indication——
Chemical Information
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CAS Number946615-43-6
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Formula Weight445.48
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Molecular FormulaC24H26F3N3O2
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Purity>98% (HPLC)
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Solubility——
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SMILESC(=C/C(NC1=C2C(=CC=C1)CCC(O)C2)=O)\C3=C(N=C(C(F)(F)F)C=C3)N4CCCCC4
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Chaoran Wu, et al. Effect of AMG0347, a Transient Receptor Potential Type V1 Receptor Antagonist, and Morphine on Pain Behavior after Plantar Incision。Anesthesiology. 2008 Jun;108(6):1100-8.?
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