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SC-99
CAS No. 882290-02-0
SC-99 ( STAT3 inhibitor SC99 )
Catalog No. M16398 CAS No. 882290-02-0
A novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 170 | Get Quote |
|
| 10MG | 263 | Get Quote |
|
| 25MG | 504 | Get Quote |
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| 50MG | 709 | Get Quote |
|
| 100MG | 1008 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameSC-99
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NoteResearch use only, not for human use.
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Brief DescriptionA novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation.
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DescriptionA novel selective STAT3 inhibitor that inhibits JAK2-STAT3 activation but has no effects on other transcription factors such as NF-κB, and kinases such as AKT, ERK, and c-Src; inhibits STAT3 phosphorylation, dimerization and nuclear translocation, downregulates STAT3-modulated gene expression and induces MM cell apoptosis; delays tumor growth in MM xenograft models (30mg/kg); orally active.
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SynonymsSTAT3 inhibitor SC99
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorSTAT
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Research Area——
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Indication——
Chemical Information
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CAS Number882290-02-0
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Formula Weight336.15
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Molecular FormulaC15H8Cl2FN3O
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Purity>98% (HPLC)
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Solubility——
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SMILESN#C/C(C(C1=CC=C(Cl)C=C1)=O)=N\NC2=CC=C(F)C(Cl)=C2
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Chemical Name(E)-N-(3-chloro-4-fluorophenyl)-2-(4-chlorophenyl)-2-oxoacetohydrazonoyl cyanide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Zhang Z, et al. Oncotarget. 2016 Feb 23;7(8):9296-308.
2. Xu Z, et al. Acta Pharmacol Sin. 2017 May;38(5):651-659.
2. Xu Z, et al. Acta Pharmacol Sin. 2017 May;38(5):651-659.
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