Stafib-2( Stafib 2 )

Catalog No. M13314 CAS No. 2097938-74-2

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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Product Name

Stafib-2
Note

Research use only, not for human use.
Brief Description

Stafib-2 (Stafib 2) is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.
Description

Stafib-2 (Stafib 2) is a potent, selective small molecule inhibitor of transcription factor STAT5b with Ki of 9 nM, >20-fold selectivity over STAT5a.
In Vitro

Stafib-2 has an extremely high affinity for STAT5b (Ki=8.8 nM).Stafib-2 (3-10 μM; 4-48 h) does not show significant activity in K562 and MDA-MB-231 cells.
In Vivo

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Synonyms

Stafib 2
Pathway

JAK/STAT Signaling
Target

STAT
Recptor

STAT
Research Area

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Indication

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CAS Number

2097938-74-2
Formula Weight

644.466
Molecular Formula

C28H26N2O12P2
Purity

>98% (HPLC)
Solubility

In Vitro:?DMSO : 50 mg/mL (77.58 mM)
SMILES

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Chemical Name

4-((2-(4-((4-phenoxyphenyl)carbamoyl)phenoxy)acetamido)methyl)-1,2-phenylene bis(dihydrogen phosphate)

1. Elumalai N, et al. Sci Rep. 2017 Apr 11;7(1):819.

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