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FLLL-32
CAS No. 1226895-15-3
FLLL-32( JAK2 Inhibitor X | FLLL32 )
Catalog No. M10870 CAS No. 1226895-15-3
FLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 1 mL x 10 mM in DMSO | 63 | In Stock |
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| 2MG | 36 | In Stock |
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| 5MG | 58 | In Stock |
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| 10MG | 81 | In Stock |
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| 25MG | 120 | In Stock |
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| 50MG | 193 | In Stock |
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| 100MG | 343 | In Stock |
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| 200MG | Get Quote | In Stock |
|
| 500MG | 823 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameFLLL-32
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NoteResearch use only, not for human use.
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Brief DescriptionFLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM).
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DescriptionFLLL-32 is a cell-permeable analog of curcumin that inhibits JAK2-mediated phosphorylation of STAT3 on Tyr705 in cancer cells (IC50=5 uM); induces apoptosis in pancreatic and breast cancer cell lines; also inhibit colony formation in soft agar and cell invasion and exhibits synergy with Doxorubicin against breast cancer cells; decreases STAT3 DNA binding activity and expression, and induces apoptosis in several cancer cell lines.
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In VitroFLLL32 specifically reduces STAT3 phosphorylation at Tyr705 (pSTAT3) and induces apoptosis at micromolar amounts in human melanoma cell lines and primary melanoma cultures.
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In Vivo——
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SynonymsJAK2 Inhibitor X | FLLL32
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PathwayJAK/STAT Signaling
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TargetSTAT
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RecptorJAK2
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1226895-15-3
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Formula Weight464.6
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Molecular FormulaC28H32O6
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Purity>98% (HPLC)
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SolubilityDMSO: 85 mg/mL (183 mM); Ethanol: 24 mg/mL (51.7 mM); Water: <1 mg/mL （ < 1 mg/ml refers to the product slightly soluble or insoluble )
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SMILESO=C(C1(C(/C=C/C2=CC=C(OC)C(OC)=C2)=O)CCCCC1)/C=C/C3=CC=C(OC)C(OC)=C3
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Chemical Name(2E,2'E)-1,1'-cyclohexylidenebis[3-(3,4-dimethoxyphenyl)]-2-propen-1-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lin L, et al. Cancer Res. 2010 Mar 15;70(6):2445-54.
2. Bill MA, et al. Mol Cancer. 2010 Jun 25;9:165.
3. Fossey SL, et al. BMC Cancer. 2011 Mar 28;11:112.
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