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Rbin-1

CAS No. 328023-11-6

Rbin-1( Ribozinoindole-1 )

Catalog No. M20815 CAS No. 328023-11-6

Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.?

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Rbin-1
  • Note
    Research use only, not for human use.
  • Brief Description
    Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.?
  • Description
    Rbin-1 is a potentspecific inhibitor of eukaryotic ribosome biogenesis.?
  • In Vitro
    Rbin-1 is a potent and reversible triazinoindole-based inhibitors of eukaryotic ribosome biogenesis. Rbin-1 inhibits recombinant full-length Mdn1’s ATPase activity. Two of the active analogs (Rbin-1 and Rbin-2) inhibit the ATPase activity by 40% at 1 uM. In particular, an analog (Rbin-2) with a bromine substituent at postion-7 is 10-fold more active than Rbin-1 (GI50=14±1 nM (Rbin-2); 136±7 nM (Rbin-1), n=4, mean±SD).
  • In Vivo
    ——
  • Synonyms
    Ribozinoindole-1
  • Pathway
    Endocrinology/Hormones
  • Target
    ATPase
  • Recptor
    ATPase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    328023-11-6
  • Formula Weight
    256.33
  • Molecular Formula
    C13H12N4S
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO:31 mg/mL (120.94 mM)
  • SMILES
    C=C(C)CSc1nnc2c(n1)[nH]c1ccccc12
  • Chemical Name
    3-((2-Methylallyl)thio)-5H-[124]triazino[56-b]indole

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Structural Insights into Mdn1 an Essential AAA Protein Required for Ribosome Biogenesis.
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