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ATPase
The electrochemical proton gradient across membranes and the acidic lumenal pH play vital bioenergetic or physiological roles in organelles, cells and tissues of animals and plants. They are required for ATP synthesis, solute transport, protein processing, exocytosis, endocytosis, etc. Proton-pumping ATPases are the major players in the transport of protons across membranes. The three classes of the ATPase family are the P-ATPase, F-ATPase and V-ATPase, the nomenclature being based on acyl phosphate intermediates, factors of oxidative phosphorylation and a pump found initially in vacuoles, respectively. F-ATPase and V-ATPase are similar in subunit structure and mechanism. However, F-ATPase is a ubiquitous ATP synthase in mitochondria, chloroplasts, and bacterial membranes, whereas V-ATPase is a proton pump in diverse endomembrane organelles such as lysosomes and endosomes.
References
1.Nakanishi-Matsui M,et al. IUBMB Life. 2006;58(5-6):318–322.
References
1.Nakanishi-Matsui M,et al. IUBMB Life. 2006;58(5-6):318–322.
Endocrinology/Hormones
ATPase
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ATPase-IN-3
catalog no : M37359
cas no: 1134203-12-5
ATPase-IN-3 is an ATPase (ATPase) inhibitor that can be used in the study of metabolism-related diseases.
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PK095
catalog no : M35967
cas no: 380314-37-4
PK095 is a proprietary compound in the guanidine - based F1F0-ATPase inhibitor family.
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Mtb ATP synthase-IN-1
catalog no : M35484
cas no: 2642394-38-3
Mtb ATP synthase-IN-1 (compound 6ab) is a potent inhibitor of Mycobacterium tuberculosis (Mtb) ATP synthase (MIC = 0.452-0.499 μg/mL) that can be used in anti-mycobacterium research, showing low cytotoxicity (Vero IC 50 > 64 μg/mL) and acceptable oral bioavailability with good metabolic stability.
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L-Palmitoylcarnitine chloride
catalog no : M34932
cas no: 18877-64-0
L-Palmitoylcarnitine chloride (Palmitoyl-L-carnitine chloride) is a fatty acid metabolite with antithrombotic properties that protects mice from ischemic stroke by counteracting intracerebral thrombosis in the tMCAO model.
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Sodium oleate
catalog no : M34835
cas no: 143-19-1
Sodium oleate (cis-9-Octadecenoic acid sodium salt) (Oleic acid sodium) is an abundant monounsaturated fatty acid sodium. Sodium oleate is a Na+/K+ ATPase activator.