RV-1729 ( RV1729;RV 1729 )

Catalog No. M11188 CAS No. 1293915-42-0

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Datasheet

HNMR

HPLC

MSDS

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Product Name

RV-1729
Note

Research use only, not for human use.
Brief Description

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM.
Description

RV-1729 is a potent, selective PI3Kδ inhibitor with IC50 of 12 nM, 2-fold selectivity for PI3Kδ relative to PI3Kγ and 16-fold over PI3Kα; inhibits PMA-induced peroxide production in U937 cells and phosphorylation of Akt in MCP1-stimulated THP1 cells with IC50 of 1.1 and 46 nM; significantly inhibits allergen-induced responses in murine models of asthma and COPD.Asthma Phase 1 Clinical
Synonyms

RV1729;RV 1729
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3K
Research Area

Inflammation/Immunology
Indication

Asthma

CAS Number

1293915-42-0
Formula Weight

735.24
Molecular Formula

C39H39ClN8O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N(CCOC)CCOC)CCCC#CC1=CC=CC(N=C(CN2N=C(C3=CC=CC(O)=C3)C4=C(N)N=CN=C42)N5CC6=CC=CC=C6Cl)=C1C5=O
Chemical Name

6-(2-((4-amino-3-(3-hydroxyphenyl)-1H-pyrazolo[3,4-d]pyrimidin-1-yl)methyl)-3-(2-chlorobenzyl)-4-oxo-3,4-dihydroquinazolin-5-yl)-N,N-bis(2-methoxyethyl)hex-5-ynamide

1. Norman P. Expert Opin Ther Pat. 2014 Apr;24(4):471-5.
2. Respivert Ltd. Crystalline PI3 kinase inhibitors. WO2013136076; 2013

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