Leniolisib ( CDZ-173;CDZ173 )

Catalog No. M11446 CAS No. 1354690-24-6

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Product Name

Leniolisib
Note

Research use only, not for human use.
Brief Description

A novel potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively.
Description

A novel potent and selective PI3Kδ inhibitor with biochemical IC50 of 11 nM; displays >20-fold, 40-fold, and 200-fold selectivity over PI3Kα, PI3Kβ, and PI3Kγ, respectively; shows 30-fold cellular selectivity over PI3Kα; inhibits a large spectrum of immune cell functions, as demonstrated in B and T cells, neutrophils, monocytes, basophils, plasmocytoid dendritic cells, and mast cells in vitro; potently inhibits antigen-specific antibody production and reduces disease symptoms in a rat collagen-induced arthritis model.Other Indication Phase 2 Clinical
Synonyms

CDZ-173;CDZ173
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

PI3Kδ;PI3Kα;PI3Kβ;DNA-PK
Research Area

Other Indications
Indication

Other Disease

CAS Number

1354690-24-6
Formula Weight

450.46
Molecular Formula

C21H25F3N6O2
Purity

>98% (HPLC)
Solubility

DMSO: ≥150 mg/mL
SMILES

CCC(=O)N1CCC(C1)NC2=NC=NC3=C2CN(CC3)C4=CC(=C(N=C4)OC)C(F)(F)F
Chemical Name

1-Propanone, 1-[(3S)-3-[[5,6,7,8-tetrahydro-6-[6-methoxy-5-(trifluoromethyl)-3-pyridinyl]pyrido[4,3-d]pyrimidin-4-yl]amino]-1-pyrrolidinyl]-

1. Klemens Hoegenauer, et al. ACS Med. Chem. Lett. DOI: 10.1021/acsmedchemlett.7b00293
2.Rao VK, et al. Blood. 2017 Nov 23;130(21):2307-2316.

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