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Splitomicin

CAS No. 5690-03-9

Splitomicin ( Splitomicin )

Catalog No. M17730 CAS No. 5690-03-9

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.

Purity : 98%

COA

Datasheet

HNMR

HPLC

MSDS

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10MG	51	In Stock
25MG	105	In Stock
50MG	164	In Stock
100MG	309	In Stock
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Biological Information

Product Name

Splitomicin
Note

Research use only, not for human use.
Brief Description

Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
Description

Splitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release.
Synonyms

Splitomicin
Pathway

PI3K/Akt/mTOR signaling
Target

PI3K
Recptor

SIRT2p
Research Area

Cardiovascular Disease
Indication

——

Chemical Information

CAS Number

5690-03-9
Formula Weight

198.22
Molecular Formula

C13H10O2
Purity

98%
Solubility

——
SMILES

O=C1CCc2c3ccccc3ccc2O1
Chemical Name

1H-benzo[f]chromen-3(2H)-one

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118.

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