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Splitomicin
CAS No. 5690-03-9
Splitomicin ( Splitomicin )
Catalog No. M17730 CAS No. 5690-03-9
Splitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
Purity : 98%
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 37 | In Stock |
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| 10MG | 51 | In Stock |
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| 25MG | 105 | In Stock |
|
| 50MG | 164 | In Stock |
|
| 100MG | 309 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameSplitomicin
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NoteResearch use only, not for human use.
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Brief DescriptionSplitomicin (IC50 of 60 μM), a specific inhibitor of NAD(+)-dependent histone deacetylase Sir2p, displays a high activity in a cell-based assay.
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DescriptionSplitomicin is a cell-permeable lactone derived from naphthol and known to be a potent selective inhibitor of Sir2 (silent information regulator 2) and HDAC. Splitomicin inhibits the NAD+-dependent deacetylase activity of Sir2 in vitro. It increases the levels of cyclic AMP by inhibiting the activity of cyclic AMP phosphodiesterase, interferes with mobilization of intracellular Ca+2 and ATP release.
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SynonymsSplitomicin
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PathwayPI3K/Akt/mTOR signaling
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TargetPI3K
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RecptorSIRT2p
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number5690-03-9
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Formula Weight198.22
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Molecular FormulaC13H10O2
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Purity98%
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Solubility——
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SMILESO=C1CCc2c3ccccc3ccc2O1
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Chemical Name1H-benzo[f]chromen-3(2H)-one
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Bedalov A, et al. Proc Natl Acad Sci U S A. 2001, 98(26), 15113-15118.
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