ROC-325

CAS No. 1859141-26-6

ROC-325( ROC 325 | ROC325 )

Catalog No. M12869 CAS No. 1859141-26-6

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
2MG 61 Get Quote
5MG 87 Get Quote
10MG 150 Get Quote
25MG 303 Get Quote
50MG 492 Get Quote
100MG 710 Get Quote
500MG 1467 Get Quote
1G Get Quote Get Quote

Biological Information

  • Product Name
    ROC-325
  • Note
    Research use only, not for human use.
  • Brief Description
    ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
  • Description
    ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ROC 325 | ROC325
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1859141-26-6
  • Formula Weight
    503.061
  • Molecular Formula
    C28H27ClN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
  • Chemical Name
    1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879. 2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.
molnova catalog
related products
  • Ferrozine monosodium...

    Ferrozine monosodium salt is a dye that reacts with divalent iron to form a stable magenta complex that can be used for the spectrophotometric determination of iron.

  • Talarozole

    Talarozole is an oral systemic all-trans retinoic acid metabolism blocking agent (RAMBA). Talarozole inhibits both CYP26A1 and CYP26B1 with IC50s of 5.4 and 0.46 nM respectively.Talarozole for the treatment of acne psoriasis and other keratinization disorders.

  • UNC669

    UNC669 is an effective and specific MBT (malignant brain tumor) inhibitor with IC50 of 4.2/3.1 uM for L3MBTL1/3.