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ROC-325

CAS No. 1859141-26-6

ROC-325( ROC 325 | ROC325 )

Catalog No. M12869 CAS No. 1859141-26-6

ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    ROC-325
  • Note
    Research use only, not for human use.
  • Brief Description
    ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy.
  • Description
    ROC-325 (ROC 325, ROC325) is a novel, orally available inhibitor of lysosomal-mediated autophagy; exhibits superior in vitro anticancer effects compared with the existing autophagy inhibitor hydroxychloroquine (HCQ) in different cancer cell lines, including accumulation of autophagosomes with undegraded cargo, lysosomal deacidification, p62 stabilization, and disruption of autophagic flux; antagonizes RCC growth and survival in an ATG5/7-dependent manner, induces apoptosis and exhibited favorable selectivity; significantly more effective at inhibiting tumor progression than HCQ, and inhibited autophagy in vivo.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ROC 325 | ROC325
  • Pathway
    Autophagy
  • Target
    Autophagy
  • Recptor
    Autophagy
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    1859141-26-6
  • Formula Weight
    503.061
  • Molecular Formula
    C28H27ClN4OS
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO : 32 mg/mL 63.61 mM; H2O : < 0.1 mg/mL
  • SMILES
    O=C1C2=C(C(C)=CC=C2NCCN(C)CCNC3=C(C=CC(Cl)=C4)C4=NC=C3)SC5=CC=CC=C51
  • Chemical Name
    1-((2-((2-((7-chloroquinolin-4-yl)amino)ethyl)(methyl)amino)ethyl)amino)-4-methyl-9H-thioxanthen-9-one

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Carew JS, et al. Clin Cancer Res. 2017 Jun 1;23(11):2869-2879. 2. Carew JS, et al. Autophagy. 2017 Apr 3;13(4):765-766.
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