ULK-101 ( ULK101 )

Catalog No. M16932 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ULK-101
Note

Research use only, not for human use.
Brief Description

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM.
Description

ULK-101 (ULK101) is a potent and selective ULK1 inhibitor with in vitro IC50 of 8.3 nM, inhibits ULK2 with IC50 of 30 nM; reduces Ser15 phosphorylation in a concentration-dependent manner in cell-based assay (EC50=390 nM), which is more potent than SBI-0206965 showing a cellular EC50 of 2.4 uM; displays desirable kinome selectivity profile; suppresses autophagy induction and autophagic flux in response to different stimuli, ULK1 inhibition sensitizes KRAS mutant lung cancer cells to nutrient stress.
Synonyms

ULK101
Pathway

Autophagy
Target

ULK
Recptor

ULK
Research Area

——
Indication

——

CAS Number

--
Formula Weight

460.45
Molecular Formula

C22H16F4N4OS
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=CC(C2=C3N=CC(C4=CC=C(F)C=C4)=CN3N=C2)=CS1)N[C@@H](C5CC5)C(F)(F)F
Chemical Name

(S)-N-(1-cyclopropyl-2,2,2-trifluoroethyl)-4-(6-(4-fluorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl)thiophene-2-carboxamide

1. Martin KR, et al. iScience. 2018 Oct 26;8:74-84. doi: 10.1016/j.isci.2018.09.012.

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