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Thapsigargin
CAS No. 67526-95-8
Thapsigargin ( G-202;G 202;G202 )
Catalog No. M15579 CAS No. 67526-95-8
A potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameThapsigargin
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells.
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DescriptionA potent, selective, non-competitive inhibitor of the sarco/endoplasmic reticulum Ca2+ ATPase (SERCA), causes ER stress and induces autophagy in mammalian cells; inhibits the Ca2+ ATPase of rat liver ER about 100% at 170 nM, but no inhibition for skeletal muscle SR; increases the concentration of cytosolic free Ca2+ in sensitive cells by an acute and highly specific arrest of the endoplasmic reticulum Ca2+ pump.
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SynonymsG-202;G 202;G202
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PathwayAutophagy
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TargetAutophagy
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RecptorAutophagy
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number67526-95-8
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Formula Weight650.76
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Molecular FormulaC34H50O12
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Purity>98% (HPLC)
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Solubility——
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SMILESCCCCCCCC(O[C@@H]1[C@@H](OC(/C(C)=C\C)=O)C(C)=C2[C@@]1([H])[C@@](C)(OC(C)=O)C[C@H](OC(CCC)=O)[C@@]([C@@]3(O)C)(O)[C@@]2([H])OC3=O)=O
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Chemical Name(3S,3aR,4S,6S,6AR,7S,8S,9bS)-6- (Acetyloxy)-2,3,3a,4,5,6,6a,7,8,9b-decahydro-3,3a-dihydroxy-3,6,9-trimethyl-8-[[(2Z)-2-methyl-1-oxo-2-butenyl]oxy]-2-oxo-4-(1-oxobutoxy)azuleno[4,5-b]furan-7-yl octanoate
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Davidson GA, et al. J Biol Chem. 1995 May 19;270(20):11731-4.
2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.
3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.
4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.
2. Thastrup O, et al. Proc Natl Acad Sci U S A. 1990 Apr;87(7):2466-70.
3. Yu M, et al. J Biol Chem. 1998 Feb 6;273(6):3542-6.
4. Panagaki T, et al. Sci Rep. 2017 Nov 23;7(1):16158.
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