Cart
sales@molnova.com
RO4929097
CAS No. 847925-91-1
RO4929097 ( RG 4733;RO 4929097 )
Catalog No. M16154 CAS No. 847925-91-1
RO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 51 | In Stock |
|
| 5MG | 80 | In Stock |
|
| 10MG | 146 | In Stock |
|
| 25MG | 264 | In Stock |
|
| 50MG | 447 | In Stock |
|
| 100MG | 660 | In Stock |
|
| 500MG | 1377 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameRO4929097
-
NoteResearch use only, not for human use.
-
Brief DescriptionRO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM.
-
DescriptionRO4929097 (RG 4733) is a potent, selective, orally active γ-secretase inhibitor with IC50 of 4 nM, inhibits Notch processing in the Notch cell-based reporter assay with IC50 of 5 nM; displays >100-fold selectivity against a panel of 75 other proteins of various types including receptors, ion channels and enzymes; inhibits Notch processing in human tumor-derived cells, inhibits the production of ICN, reducing the expression of the downstream Notch target Hes1 in A549 cells; demonstrates in vivo efficacy in A549 xenograft model.Lung Cancer Phase 2 Discontinued
-
SynonymsRG 4733;RO 4929097
-
PathwayWnt/Notch/Hedgehog
-
Targetγ-secretase
-
RecptorAβ40;γsecretase;γsecretase(ICN);Notch
-
Research AreaCancer
-
IndicationLung Cancer
Chemical Information
-
CAS Number847925-91-1
-
Formula Weight469.40
-
Molecular FormulaC22H20F5N3O3
-
Purity>98% (HPLC)
-
SolubilityDMSO: ≥ 49 mg/mL
-
SMILESO=C(N[C@H]1C2=CC=CC=C2C3=CC=CC=C3NC1=O)C(C)(C)C(NCC(F)(F)C(F)(F)F)=O
-
Chemical NamePropanediamide, N1-[(7S)-6,7-dihydro-6-oxo-5H-dibenz[b,d]azepin-7-yl]-2,2-dimethyl-N3-(2,2,3,3,3-pentafluoropropyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Debeb BG, et al. Breast Cancer Res Treat. 2012 Jul;134(2):495-510.
2. Kaur G, et al. Cancer Lett. 2016 Feb 28;371(2):225-39.
3. He W, et al. Mol Oncol. 2011 Jun;5(3):292-301.
4. Luistro L, et al. Cancer Res. 2009 Oct 1;69(19):7672-80.
2. Kaur G, et al. Cancer Lett. 2016 Feb 28;371(2):225-39.
3. He W, et al. Mol Oncol. 2011 Jun;5(3):292-301.
4. Luistro L, et al. Cancer Res. 2009 Oct 1;69(19):7672-80.
molnova catalog
related products
-
MK-0752
A potent γ-secretase inhibitor that shows dose-dependent reduction of Aβ40 with an IC50 of 5 nM in human SH-SY5Y cells.
-
MRK-003
A potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
-
Semagacestat
A potent γ-secretase inhibitor that inhibits β-amyloid Aβ42, Aβ38 and Aβ40 with IC50 of 10.9, 12 and 12.1 nM, respectively.
