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MRK-003
CAS No. 623165-93-5
MRK-003( MRK 003 | MRK003 )
Catalog No. M15359 CAS No. 623165-93-5
A potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 1413 | In Stock |
|
| 50MG | 2862 | In Stock |
|
| 100MG | 3870 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameMRK-003
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NoteResearch use only, not for human use.
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Brief DescriptionA potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells.
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DescriptionA potent γ-secretase inhibitor with IC50 of 0.4 nM, inhibition of Aβ secretion from SH-SY5Y SPA4CT cells; inhibits the γ-secretase-mediated cleavage of the Notch receptor, reduces tumor cell proliferation, inhibits serum independence, and induces apoptosis in vitro and in vivo using mouse xenograft models.Pancreatic Cancer Preclinical.
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In Vitro——
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In Vivo——
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SynonymsMRK 003 | MRK003
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PathwayWnt/Notch/Hedgehog
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Targetγ-secretase
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Recptorγ-secretase
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Research AreaCancer
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IndicationPancreatic Cancer
Chemical Information
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CAS Number623165-93-5
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Formula Weight551.59
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Molecular FormulaC25H31F6N3O2S
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Purity>98% (HPLC)
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Solubility——
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SMILESFC(C1CCN(C/C=C/C2=CC=C3C(C[C@@]4([H])CC[C@]([C@@]4(CN5CC(F)(F)F)NS5(=O)=O)([H])C3)=C2)CC1)(F)F
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Chemical Name(3R,6'S,9'R)-5-(2,2,2-trifluoroethyl)-2'-((E)-3-(4-(trifluoromethyl)piperidin-1-yl)prop-1-en-1-yl)-5',6',7',8',9',10'-hexahydrospiro[[1,2,5]thiadiazolidine-3,11'-[6,9]methanobenzo[8]annulene] 1,1-dioxide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Lewis HD, et al. Chem Biol. 2007 Feb;14(2):209-19.
2. Sparey T, et al. Bioorg Med Chem Lett. 2005 Oct 1;15(19):4212-6.
3. Konishi J, et al. Cancer Res. 2007 Sep 1;67(17):8051-7.
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