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PF-06648671
CAS No. 1587727-31-8
PF-06648671( PF6648671 )
Catalog No. M12266 CAS No. 1587727-31-8
PF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 896 | In Stock |
|
| 50MG | 3222 | In Stock |
|
| 100MG | 4410 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePF-06648671
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NoteResearch use only, not for human use.
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Brief DescriptionPF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.
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DescriptionPF-06648671 (PF6648671) is a novel oral γ-secretase modulator being developed for the treatment of Alzheimer's disease.Alzheimer Disease Phase 1 Discontinued.
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In VitroIn a cell-based assay, PF-06648671 reduces Aβ42 and Aβ40 , with concomitant increases in Aβ37 and Aβ38, without inhibiting the cleavage of Notch or other substrates.
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In VivoPF-06648671 demonstrates reduces Aβ42 within the brain and CSF following acute oral administration in animals.
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SynonymsPF6648671
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PathwayWnt/Notch/Hedgehog
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Targetγ-secretase
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Recptorγ-secretase
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Research Area——
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Indication——
Chemical Information
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CAS Number1587727-31-8
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Formula Weight538.928
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Molecular FormulaC25H23ClF4N4O3
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C1C(N2CCN1[C@H]([C@H]3O[C@@H](C4=CC(F)=C(Cl)C=C4C(F)(F)F)CC3)C)=CC=C(N5C=C(C)N=C5)C2=O
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Chemical Name2H-Pyrido[1,2-a]pyrazine-1,6-dione, 2-[(1S)-1-[(2S,5R)-5-[4-chloro-5-fluoro-2-(trifluoromethyl)phenyl]tetrahydro-2-furanyl]ethyl]-3,4-dihydro-7-(4-methyl-1H-imidazol-1-yl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
molnova catalog
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