E-2012 ( E2012 )

Catalog No. M16327 CAS No. 870843-42-8

A potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37).

Purity : >98% (HPLC)

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Biological Information

Product Name

E-2012
Note

Research use only, not for human use.
Brief Description

A potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37).
Description

A potent, second-generation γ-secretase modulator that decreases Aβ(1-39), Aβ(1-40) and A(1-42), and increases Aβ(1-37).Alzheimer's Disease Discontinued
Synonyms

E2012
Pathway

Wnt/Notch/Hedgehog
Target

γ-secretase
Recptor

γ-secretase
Research Area

Neurological Disease
Indication

Alzheimer Disease

Chemical Information

CAS Number

870843-42-8
Formula Weight

419.49
Molecular Formula

C25H26FN3O2
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

O=C1N([C@H](C2=CC=C(F)C=C2)C)CCC/C1=C\C3=CC=C(N4C=C(C)N=C4)C(OC)=C3
Chemical Name

2-Piperidinone, 1-[(1S)-1-(4-fluorophenyl)ethyl]-3-[[3-methoxy-4-(4-methyl-1H-imidazol-1-yl)phenyl]methylene]-, (3E)-

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Portelius E, et al. J Alzheimers Dis. 2010;21(3):1005-12.
2. Borgegard T, et al. J Biol Chem. 2012 Apr 6;287(15):11810-9.
3. Borghys H, et al. J Alzheimers Dis. 2012;28(4):809-22.

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