QTX125 ( QTX 125;QTX-125 )

Catalog No. M11154 CAS No. 1279698-31-5

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

QTX125
Note

Research use only, not for human use.
Brief Description

QTX125 (QTX-125) is a novel potent, selective HDAC6 inhibitor, displays excellent selectivity over other HDACs.
Description

QTX125 (QTX-125) is a novel potent, selective HDAC6 inhibitor, displays excellent selectivity over other HDACs; strongly reduces cell viability with IC50 values of 0.120 and 0.182 uM in two primary samples obtained from patients with MCL; causes cell-growth inhibition and programmed cell death in association with increased levels of acetylated α-tubulin, also antitumoral effect is particularly evident in MCL models, both in culture and in vivo, surpassing the efficacy of currently available HDAC6 inhibitors.
Synonyms

QTX 125;QTX-125
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1279698-31-5
Formula Weight

417.42
Molecular Formula

C23H19N3O5
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(C1=C(C2=COC=C2)C=C(C3=CC=C(O)C=C3)N1)NCC4=CC=C(C(NO)=O)C=C4
Chemical Name

3-(3-furyl)-N-{4-[(hydroxyamino)carbonyl]benzyl}-5-(4-hydroxyphenyl)-1H-pyrrole2-carboxamide

1. Perez-Salvia M, et al. Haematologica. 2018 Jun 7. pii: haematol.2018.189241.

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