ACY-775 ( ACY 775;ACY775 )

Catalog No. M11553 CAS No. 1375466-18-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

ACY-775
Note

Research use only, not for human use.
Brief Description

ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability.
Description

ACY-775 (ACY775) is a potent and specific HDAC6 inhibitor (IC50=7.5 nM) with improved brain bioavailability; 60-1500 fold selectivity over class I HDACs; no activity against all other class II HDAC isoforms (IC50>1uM); induce dramatic increases in α-tubulin acetylation in brain and stimulate mouse exploratory behaviors; increases the innervation of the neuromuscular junctions in the gastrocnemius muscle and improves the motor and sensory nerve conduction in the mutant HSPB1-induced CMT2 mouse model.
Synonyms

ACY 775;ACY775
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1375466-18-4
Formula Weight

330.36
Molecular Formula

C17H19FN4O2
Purity

>98% (HPLC)
Solubility

DMSO : 100 mg/mL 302.70 mM
SMILES

O=C(C1=CN=C(NC2(C3=CC=CC(F)=C3)CCCCC2)N=C1)NO
Chemical Name

2-((1-(3-fluorophenyl)cyclohexyl)amino)-N-hydroxypyrimidine-5-carboxamide

1. Jochems J, et al. Neuropsychopharmacology. 2014 Jan;39(2):389-400.
2. Benoy V, et al. Neurotherapeutics. 2017 Apr;14(2):417-428.

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