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CI-994
CAS No. 112522-64-2
CI-994 ( Acetyldinaline;Tacedinaline;PD-123654;Goe-5549 )
Catalog No. M10439 CAS No. 112522-64-2
A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 10MG | 39 | In Stock |
|
| 50MG | 59 | In Stock |
|
| 100MG | 87 | In Stock |
|
| 200MG | 154 | In Stock |
|
| 500MG | 332 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameCI-994
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
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DescriptionA potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively; show no significant inhibitory activity against HDAC8 (IC50>20 uM); reduces S phase level and increases apoptosis in A-549 and LX-1 cells; demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.Breast Cancer Phase 2 Discontinued
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SynonymsAcetyldinaline;Tacedinaline;PD-123654;Goe-5549
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC1;HDAC2;HDAC3
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Research AreaCancer
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IndicationBreast Cancer
Chemical Information
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CAS Number112522-64-2
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Formula Weight269.30
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Molecular FormulaC15H15N3O2
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 58 mg/mL
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SMILESO=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2
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Chemical NameBenzamide, 4-(acetylamino)-N-(2-aminophenyl)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
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