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CI-994

CAS No. 112522-64-2

CI-994 ( Acetyldinaline;Tacedinaline;PD-123654;Goe-5549 )

Catalog No. M10439 CAS No. 112522-64-2

A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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50MG 59 In Stock
100MG 87 In Stock
200MG 154 In Stock
500MG 332 In Stock
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Biological Information

  • Product Name
    CI-994
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively.
  • Description
    A potent, selective class I HDAC inhibitor with IC50 of 0.9/0.9/1.2 uM for HDAC1/2/3, respectively; show no significant inhibitory activity against HDAC8 (IC50>20 uM); reduces S phase level and increases apoptosis in A-549 and LX-1 cells; demonstrates antitumor activity against several tumor models, including the chemo-resistant mouse pancreatic ductal carcinoma as well as the human prostate tumor model LNCaP.Breast Cancer Phase 2 Discontinued
  • Synonyms
    Acetyldinaline;Tacedinaline;PD-123654;Goe-5549
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC1;HDAC2;HDAC3
  • Research Area
    Cancer
  • Indication
    Breast Cancer

Chemical Information

  • CAS Number
    112522-64-2
  • Formula Weight
    269.30
  • Molecular Formula
    C15H15N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 58 mg/mL
  • SMILES
    O=C(NC1=CC=CC=C1N)C2=CC=C(NC(C)=O)C=C2
  • Chemical Name
    Benzamide, 4-(acetylamino)-N-(2-aminophenyl)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Moradei OM, et al. J Med Chem. 2007 Nov 15;50(23):5543-6.
2. el-Beltagi HM, et al. Cancer Res. 1993 Jul 1;53(13):3008-14.
3. Loprevite M, et al. Oncol Res. 2005;15(1):39-48.
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