Marbostat-100 ( Marbostat 100 )

Catalog No. M12908 CAS No. 1876450-69-9

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Marbostat-100
Note

Research use only, not for human use.
Brief Description

Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM.
Description

Marbostat-100 is a potent, selective HDAC6 inhibitor with Ki of 0.7 nM, displays >200-fold selectivity over HDAC1-5, and HDAC7-10; Marbostat-100 is a more selective HDAC6i than previously established well-characterized compounds; Marbostat-100 is well tolerated by mice and demonstrates in vivo anti-inflammatory activity against collagen type II induced arthritis, represents a most selective known HDAC6i and the possibility for clinical evaluation of a HDAC isoform-specific drug.
Synonyms

Marbostat 100
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

1876450-69-9
Formula Weight

404.43
Molecular Formula

C22H20N4O4
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

N-Hydroxy-4-((4-methyl-3,5-dioxo-3,4,5,6-tetrahydro-2,6-methano[1,3]diazocino[5,6-b]indol-11(1H)-yl)methyl)benzamide

1. Sellmer A, et al. J Med Chem. 2018 Apr 6. doi: 10.1021/acs.jmedchem.7b01593.

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