Pristimerin ( Pristimerin; Celastrol-methylether; UNII-28ZK7PR57S )

Catalog No. M17913 CAS No. 1258-84-0

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Pristimerin
Note

Research use only, not for human use.
Brief Description

Pristimerin has anticancer activity, treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells.
Description

Pristimerin has anticancer activity , treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells. Pristimerin down-regulates the expression of pro-inflammatory mediators through blocking of NF-κB activation by inhibiting interconnected ROS/IKK/NF-κB signaling pathways, can effectively inhibit both arthritic inflammation and cartilage and bone damage in the joints.
Synonyms

Pristimerin; Celastrol-methylether; UNII-28ZK7PR57S
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

NF-κB
Research Area

Cancer
Indication

——

CAS Number

1258-84-0
Formula Weight

464.64
Molecular Formula

C30H40O4
Purity

98%
Solubility

DMSO : 20 mg/mL 43.04 mM; H2O : < 0.1 mg/mL
SMILES

CC1=C(C(=O)C=C2C1=CC=C3C2(CCC4(C3(CCC5(C4CC(CC5)(C)C(=O)OC)C)C)C)C)O
Chemical Name

methyl (2S,4aS,6aR,12bR,14aR,14bR)-10-hydroxy-2,4a,6a,9,12b,14a-hexamethyl-11-oxo-1,2,3,4,4a,5,6,6a,11,12b,13,14,14a,14b-tetradecahydropicene-2-carboxylate