Cart
sales@molnova.com
AK-1
CAS No. 330461-64-8
AK-1 ( DA-42784; KB-120200; DA42784; KB120200; J018989; DA 42784; KB 120200; J 018989 )
Catalog No. M14095 CAS No. 330461-64-8
A potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 42 | In Stock |
|
| 10MG | 69 | In Stock |
|
| 25MG | 147 | In Stock |
|
| 50MG | 251 | In Stock |
|
| 100MG | 378 | In Stock |
|
| 200MG | Get Quote | In Stock |
|
| 500MG | Get Quote | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
-
Product NameAK-1
-
NoteResearch use only, not for human use.
-
Brief DescriptionA potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM.
-
DescriptionA potent, selective and brain-permeable SIRT2 inhibitor with IC50 of 12.5 uM; induces proteasomal degradation of the Snail transcription factor through inactivation of the NF-κB/CSN2 pathway; increases the ubiquitination of HIF-1α in a VHL-dependent manner, leading to the degradation of HIF-1α via a proteasomal pathway.
-
SynonymsDA-42784; KB-120200; DA42784; KB120200; J018989; DA 42784; KB 120200; J 018989
-
PathwayChromatin/Epigenetic
-
TargetSirtuin
-
RecptorSirtuin
-
Research AreaMetabolic Disease
-
Indication——
Chemical Information
-
CAS Number330461-64-8
-
Formula Weight403.45
-
Molecular FormulaC19H21N3O5S
-
Purity>98% (HPLC)
-
SolubilityDMSO
-
SMILESO=C(NC1=CC=CC([N+]([O-])=O)=C1)C2=CC=CC(S(=O)(N3CCCCCC3)=O)=C2
-
Chemical NameBenzamide, 3-[(hexahydro-1H-azepin-1-yl)sulfonyl]-N-(3-nitrophenyl)-
Shipping & Storage Information
-
Storage(-20℃)
-
ShippingWith Ice Pack
-
Stability≥ 2 years
Reference
1. Luthi-Carter R, et al. Proc Natl Acad Sci U S A. 2010 Apr 27;107(17):7927-32.
2. Lee SD, et al. Cancer Lett. 2016 Apr 1;373(1):138-45.
3. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.
2. Lee SD, et al. Cancer Lett. 2016 Apr 1;373(1):138-45.
3. Taylor DM, et al. ACS Chem Biol. 2011 Jun 17;6(6):540-6.
molnova catalog
related products
-
Selisistat R-enantio...
Selisistat R-enantiomer is a SIRT1 inhibitor with much less activity than the R-enantiomer of Selisistat (IC50 of SIRT1 > 100 μM).
-
E1231
E1231 (E-1231) is a small molecule SIRT1 activator with EC50 of 0.83 uM.
-
Pristimerin
Pristimerin has anticancer activity, treatment with Pristimerin may be a potential strategy for the suppression of hypoxia-induced metastasis through the reversal of hypoxia-induced stem cell characteristics and EMT in cancer cells.
