FIIN-3 ( FIIN3; FIIN 3; FIIN-3 )

Catalog No. M17353 CAS No. 1637735-84-2

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Datasheet

HNMR

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Product Name

FIIN-3
Note

Research use only, not for human use.
Brief Description

FIIN-3 is an irreversible inhibitor of FGFR.
Description

FIIN-3 is a potent, selective, irreversible and the next-generation covalent FGFR inhibitor. FIIN-3 is the first inhibitor that can potently inhibit the proliferation of cells dependent upon the gatekeeper mutants of FGFR1 or FGFR2, which confer resistance to first-generation clinical FGFR inhibitors such as NVP-BGJ398 and AZD4547. FIIN-3 has the unprecedented ability to inhibit both the EGF receptor (EGFR) and FGFR covalently by targeting two distinct cysteine residues. FIIN-3 bound with FGFR4 V550L and EGFR L858R.
Synonyms

FIIN3; FIIN 3; FIIN-3
Pathway

Chromatin/Epigenetic
Target

Sirtuin
Recptor

FGFR1; FGFR2; FGFR3; FGFR4
Research Area

Cancer
Indication

——

CAS Number

1637735-84-2
Formula Weight

691.61
Molecular Formula

C34H36Cl2N8O4
Purity

98%
Solubility

DMSO : 10 mg/mL 14.46 mM;
SMILES

C(=O)(C=C)Nc1ccc(cc1)CN(c1ncnc(c1)Nc1ccc(cc1)N1CCN(CC1)C)C(=O)Nc1c(c(cc(c1Cl)OC)OC)Cl
Chemical Name

N-(4-((3-(2,6-dichloro-3,5-dimethoxyphenyl)-1-(6-((4-(4-methylpiperazin-1-yl)phenyl)amino)pyrimidin-4-yl)ureido)methyl)phenyl)acrylamide

1.Tan L et al. Proc Natl Acad Sci U S A, 2014 Nov 11, 111(45):E4869-77

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