PR-619

CAS No. 2645-32-1

PR-619 ( 2,6-Diamino-3,5-dithiocyanopyridine; DUB Inhibitor V )

Catalog No. M13810 CAS No. 2645-32-1

PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.

Purity : >98%(HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
Size Price / USD Stock Quantity
5MG 41 In Stock
10MG 65 In Stock
25MG 113 In Stock
50MG 176 In Stock
100MG 267 In Stock
200MG 401 In Stock
500MG Get Quote In Stock
1G Get Quote In Stock

Biological Information

  • Product Name
    PR-619
  • Note
    Research use only, not for human use.
  • Brief Description
    PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
  • Description
    PR-619 is a non-selective, reversible inhibitor of the deubiquitinylating enzymes (DUBs) with EC50 of 1-20 μM in a cell-free assay.
  • Synonyms
    2,6-Diamino-3,5-dithiocyanopyridine; DUB Inhibitor V
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    JOSD2; SENP6 core; UCH-L3; USP4; USP8
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    2645-32-1
  • Formula Weight
    223.33
  • Molecular Formula
    C7H5N5S2
  • Purity
    >98%(HPLC)
  • Solubility
    DMSO: 45 mg/mL (201.54 mM)
  • SMILES
    N#CSC1=C(N)N=C(N)C(SC#N)=C1
  • Chemical Name
    (2,6-diamino-5-thiocyanatopyridin-3-yl) thiocyanate

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1.Altun M, et al. Chem Biol, 2011, 18(11), 1401-1412.
molnova catalog
related products
  • USP30 inhibitor 18

    USP30 inhibitor 18 is a selective inhibitor of USP30 (IC50 = 0.02 μM). USP30 inhibitor 18 is able to accelerate mitophagy and increase protein ubiquitination.

  • XL 188

    XL188 (XL-188) is a potent, selective, non-covalent active-site inhibitor of USP7 with IC50 of 90 nM and 193 nM for USP7 full length enzyme and catalytic domain, respectively.

  • NSC112200

    NSC112200 is a chemical inhibitor of the EZH2 deubiquitinase ZRANB1 (at 10 uM), destabilizes EZH2.