EOAI3402143 ( Deubiquitinase inhibitor G9;EOAI 3402143 )

Catalog No. M12594 CAS No. 1699750-95-2

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Product Name

EOAI3402143
Note

Research use only, not for human use.
Brief Description

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor.
Description

EOAI3402143 (Deubiquitinase inhibitor G9, EOAI 3402143) is a novel covalent deubiquitinase Usp9x/Usp24 inhibitor with increased aqueous solubility and greater cellular Usp9x inhibitory activity than WP1130; displays nM apoptotic activity against other myeloma cell lines and diffuse large B-cell lymphomas cells; increases tumor cell apoptosis, and fully blocks or regresses myeloma tumors in mice; also inhibis Usp5.
Synonyms

Deubiquitinase inhibitor G9;EOAI 3402143
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

CAS Number

1699750-95-2
Formula Weight

503.42
Molecular Formula

C25H28Cl2N4O3
Purity

>98% (HPLC)
Solubility

DMSO : 50 mg/mL 99.32 mM; H2O : < 0.1 mg/mL
SMILES

CCCC(C1=CC=C(C=C1)OCCN2CCOCC2)NC(=O)C(=CC3=C(C=CC(=N3)Cl)Cl)C#N
Chemical Name

(E)-2-cyano-3-(3,6-dichloropyridin-2-yl)-N-(1-(4-(2-morpholinoethoxy)phenyl)butyl)acrylamide

1. Peterson LF, et al. Blood. 2015 Jun 4;125(23):3588-97.
2. Potu H, et al. Oncotarget. 2014 Jul 30;5(14):5559-69.

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