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Home - Products - Proteasome/Ubiquitin - DUB - GNE-6640

GNE-6640

CAS No. 2009273-67-8

GNE-6640 ( GNE 6640;GNE6640 )

Catalog No. M13134 CAS No. 2009273-67-8

GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    GNE-6640
  • Note
    Research use only, not for human use.
  • Brief Description
    GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
  • Description
    GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM.
  • Synonyms
    GNE 6640;GNE6640
  • Pathway
    Proteasome/Ubiquitin
  • Target
    DUB
  • Recptor
    DUB
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    2009273-67-8
  • Formula Weight
    330.39
  • Molecular Formula
    C20H18N4O
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
  • Chemical Name
    4-[2-Amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.
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