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GNE-6640

CAS No. 2009273-67-8

GNE-6640 ( GNE 6640;GNE6640 )

Catalog No. M13134 CAS No. 2009273-67-8

GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.

Purity : >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

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Size	Price / USD	Stock	Quantity
2MG	84	In Stock
5MG	140	In Stock
10MG	237	In Stock
25MG	507	In Stock
50MG	731	In Stock
100MG	1017	In Stock
200MG	Get Quote	In Stock
500MG	Get Quote	In Stock
1G	Get Quote	In Stock

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Biological Information

Product Name

GNE-6640
Note

Research use only, not for human use.
Brief Description

GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM.
Description

GNE-6640 (GNE6640) is a potent, selective USP7 inhibitor with IC50 of 0.75 uM; dislpalys selectivity over USP47 and USP5 (IC50>200 uM); promotes endogenous MDM2 ubiquitination, stabilized p53 and upregulated p21, induces tumour cell death and enhances cytotoxicity with chemotherapeutic agents and targeted compounds, including PIM kinase inhibitors; decreased viability of 108 cell lines with IC50 <10 uM.
Synonyms

GNE 6640;GNE6640
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

DUB
Research Area

——
Indication

——

Chemical Information

CAS Number

2009273-67-8
Formula Weight

330.39
Molecular Formula

C20H18N4O
Purity

>98% (HPLC)
Solubility

10 mM in DMSO
SMILES

OC1=CC=C(C2=C(CC)C(C3=CC4=C(NN=C4)C=C3)=CN=C2N)C=C1
Chemical Name

4-[2-Amino-4-ethyl-5-(1H-indazol-5-yl)-3-pyridyl]phenol

Shipping & Storage Information

Storage

(-20℃)
Shipping

With Ice Pack
Stability

≥ 2 years

Reference

1. Kategaya L, et al. Nature. 2017 Oct 26;550(7677):534-538.

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