NSC632839 ( NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6 )

Catalog No. M12253 CAS No. 157654-67-6

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Datasheet

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HPLC

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Product Name

NSC632839
Note

Research use only, not for human use.
Brief Description

A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases.
Description

A small molecule inhibitor of ubiquitin-proteasome system by inhibiting the ubiquitin isopeptidases; induce a unique apoptotic pathway, which includes a Bcl-2-dependent but apoptosome-independent mitochondrial pathway with up-regulation of the BH3-only protein Noxa, stabilization of the IAP antagonist Smac, but also the involvement of the death receptor pathway.
Synonyms

NSC-632839;NSC 632839;Ubiquitin Isopeptidase-IN-F6
Pathway

Proteasome/Ubiquitin
Target

DUB
Recptor

SENP2;USP2;USP7
Research Area

Cancer
Indication

——

CAS Number

157654-67-6
Formula Weight

339.86
Molecular Formula

C21H22ClNO
Purity

>98% (HPLC)
Solubility

DMSO: 6.2 mg/mL (Need warming)
SMILES

CC1=CC=C(C=C1)C=C2CNCC(=CC3=CC=C(C=C3)C)C2=O.Cl
Chemical Name

4-Piperidinone, 3,5-bis[(4-methylphenyl)methylene]-, hydrochloride (1:1)

1. Aleo E, et al. Cancer Res. 2006 Sep 15;66(18):9235-44.
2. Nicholson B, et al. Protein Sci. 2008 Jun;17(6):1035-43.

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