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PHA-793887

CAS No. 718630-59-2

PHA-793887 ( PHA 793887;PHA793887 )

Catalog No. M15748 CAS No. 718630-59-2

A potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PHA-793887
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7.
  • Description
    A potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7; shows good efficacy in the human ovarian A2780, colon HCT-116 and pancreatic BX-PC3 carcinoma xenograft models; suitable for intravenous dosing.
  • Synonyms
    PHA 793887;PHA793887
  • Pathway
    Angiogenesis
  • Target
    CDK
  • Recptor
    CDK1/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p25;CDK7/CyclinH
  • Research Area
    Cancer
  • Indication
    ——

Chemical Information

  • CAS Number
    718630-59-2
  • Formula Weight
    361.48
  • Molecular Formula
    C19H31N5O2
  • Purity
    >98% (HPLC)
  • Solubility
    10 mM in DMSO
  • SMILES
    CC(C)CC(=O)NC1=NNC2=C1CN(C(=O)C1CCN(C)CC1)C2(C)C
  • Chemical Name
    Butanamide, 3-methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Brasca MG, et al. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53.
2. Locatelli G, et al. Mol Cancer Ther. 2010 May;9(5):1265-73.
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