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PHA-793887
CAS No. 718630-59-2
PHA-793887 ( PHA 793887;PHA793887 )
Catalog No. M15748 CAS No. 718630-59-2
A potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 58 | In Stock |
|
| 5MG | 96 | In Stock |
|
| 10MG | 146 | In Stock |
|
| 25MG | 293 | In Stock |
|
| 50MG | 500 | In Stock |
|
| 100MG | 705 | In Stock |
|
| 500MG | 1485 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NamePHA-793887
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NoteResearch use only, not for human use.
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Brief DescriptionA potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7.
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DescriptionA potent inhibitor of CDK2/5/7 with IC50 of 8/5/10 nM respectively; >6-fold less potency on CDK1/4/7; shows good efficacy in the human ovarian A2780, colon HCT-116 and pancreatic BX-PC3 carcinoma xenograft models; suitable for intravenous dosing.
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SynonymsPHA 793887;PHA793887
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PathwayAngiogenesis
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TargetCDK
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RecptorCDK1/CyclinB;CDK2/CyclinA;CDK2/CyclinE;CDK5/p25;CDK7/CyclinH
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number718630-59-2
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Formula Weight361.48
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Molecular FormulaC19H31N5O2
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESCC(C)CC(=O)NC1=NNC2=C1CN(C(=O)C1CCN(C)CC1)C2(C)C
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Chemical NameButanamide, 3-methyl-N-[1,4,5,6-tetrahydro-6,6-dimethyl-5-[(1-methyl-4-piperidinyl)carbonyl]pyrrolo[3,4-c]pyrazol-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Brasca MG, et al. Bioorg Med Chem. 2010 Mar 1;18(5):1844-53.
2. Locatelli G, et al. Mol Cancer Ther. 2010 May;9(5):1265-73.
2. Locatelli G, et al. Mol Cancer Ther. 2010 May;9(5):1265-73.
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