Amt-87( —— )

Catalog No. M12314 CAS No. 1609019-52-4

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

Amt-87
Note

Research use only, not for human use.
Brief Description

Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186.
Description

Amt-87 is a HIV latency-reversal agent that reactivates latent HIV at the transcriptional level, promotes phosphorylation of CDK9 T-loop at Thr186; induces P-TEFb dissociation from 7SK snRNP and promotes Tat-SEC formation on HIV-1 LTR, dissociates P-TEFb from 7SK snRNP and promotes Tat-SEC formation at the HIV-1 promoter; synergizes with prostratin and JQ1 to reverse HIV latency and reactivate viral transcription.
In Vitro

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In Vivo

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Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

1609019-52-4
Formula Weight

492.612
Molecular Formula

C30H36O6
Purity

>98% (HPLC)
Solubility

——
SMILES

CC1=CC(=C(C=C1)O)C(=O)C=CC2=CC(=C(C=C2OCOC)OCOC)C34CC5CC(C3)CC(C5)C4
Chemical Name

(E)-3-(5-(adamantan-1-yl)-2,4-bis(methoxymethoxy) phenyl)-1-(2-hydroxy-5-methylphenyl)prop-2-en-1-one

1. Wu J, et al. Sci Rep. 2017 Sep 6;7(1):10657.

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