FMF-04-159-2 ( —— )

Catalog No. M16940 CAS No.

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

FMF-04-159-2
Note

Research use only, not for human use.
Brief Description

FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18).
Description

FMF-04-159-2 is a potent, selective, covalent CDK14 inhibitor (IC50=86 nM) with pan-TAIRE family specificity (CDKs 14-18); potently inhibited the TAIRE kinases CDK14, CDK16, CDK17, and CDK18; CDK14 was potently engaged by FMF-04-159-2 (IC50=39.6 nM), and this engagement was sustained after a 2-h, compound washout (IC50=56.3 nM), indicates irreversible binding; FMF-04-159-2 is a valuable tool for study of CDK14 kinase function.
Synonyms

——
Pathway

Angiogenesis
Target

CDK
Recptor

CDK
Research Area

——
Indication

——

CAS Number

--
Formula Weight

683.00
Molecular Formula

C28H30Cl3N7O5S
Purity

>98% (HPLC)
Solubility

——
SMILES

——
Chemical Name

(E)-N-(1-((3-(4-(dimethylamino)but-2-enamido)phenyl)sulfonyl)piperidin-4-yl)-4-(2,4,6-trichlorobenzamido)-1H-pyrazole-3-carboxamide

1. Ferguson FM, et al. Cell Chem Biol. 2019 Mar 11. pii: S2451-9456(19)30070-4.

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