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PF-6689840
CAS No. 1799790-53-6
PF-6689840( PF6689840 )
Catalog No. M12729 CAS No. 1799790-53-6
PF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamePF-6689840
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NoteResearch use only, not for human use.
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Brief DescriptionPF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays.
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DescriptionPF-6689840 (PF6689840) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 54 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.25 uM; demonstrates superior kinase selectivity compared to the Type I inhibitors; inhibits tumor cell growth, which is independent of PTK6 expression levels in cells.
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In Vitro——
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In Vivo——
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SynonymsPF6689840
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PathwayTyrosine Kinase
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TargetBreast Tumor Kinase
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RecptorBreast Tumor Kinase
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Research Area——
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Indication——
Chemical Information
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CAS Number1799790-53-6
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Formula Weight521.473
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Molecular FormulaC24H23F4N5O4
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name2-(((3R,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.
molnova catalog
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