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PF-6683324

CAS No. 1799788-94-5

PF-6683324( PF6683324 )

Catalog No. M12728 CAS No. 1799788-94-5

PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    PF-6683324
  • Note
    Research use only, not for human use.
  • Brief Description
    PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays.
  • Description
    PF-6683324 (PF6683324) is a potent and selective Type II PTK6/Brk inhibitor with IC50 of 76 nM in biochemical assays; inhibits PTK6 phosphorylation at Y342 in engineered HET293T cells overexpressing PTK6 WT with IC50 of 0.7 uM; demonstrates superior kinase selectivity compared to the Type I inhibitors.
  • In Vitro
    PF-6683324 (Trk-IN-4) (Compound 10b) exhibits superb Trk selectivity with >95% inhibition of TrkA and >40% inhibition of only 1 other kinase VEGFR2 (cell-based assay for VEGFR2 IC50>5 μM).
  • In Vivo
    ——
  • Synonyms
    PF6683324
  • Pathway
    Tyrosine Kinase
  • Target
    Breast Tumor Kinase
  • Recptor
    Breast Tumor Kinase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    1799788-94-5
  • Formula Weight
    521.473
  • Molecular Formula
    C24H23F4N5O4
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : ≥ 100 mg/mL (191.77 mM)
  • SMILES
    O=C(N)C1=C(O[C@H]2[C@@H](F)CN(C(CC3=CC=C(OC(F)(F)F)C=C3)=O)CC2)N=CC(C4=CN(C)C=N4)=C1
  • Chemical Name
    2-(((3S,4R)-3-fluoro-1-(2-(4-(trifluoromethoxy)phenyl)acetyl)piperidin-4-yl)oxy)-5-(1-methyl-1H-imidazol-4-yl)nicotinamide

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Qiu L, et al. PLoS One. 2018 Jun 7;13(6):e0198374.
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