XMU-MP-2

Research use only, not for human use.

XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM.

XMU-MP-2 is a potent and selective BRK/PTK6 (breast tumor kinase) inhibitor with biochemical IC50 of 3.2 nM; inhibits the autophosphorylation of BRK Y342 in dose-dependent manner (maximum inhibition at 500 nM), abolishes phosphorylation levels of STAT3 Y705 and STAT5 Y694; blocks proliferation and survival of BRK-transformed Ba/F3 cells with IC50 of 29.7 nM; cooperates strongly with HER2 inhibitor or ER blockade to block breast cancer cell proliferation in vitro and in vivo.

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XMUMP-2 | XMU-MP2 | XMU MP 2 | XMU-MP-2

Tyrosine Kinase

Breast Tumor Kinase

Breast Tumor Kinase

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2031152-10-8

618.665

C32H33F3N8O2

>98% (HPLC)

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O=C(NC1=CC=C(C)C(N2CC3=CN=C(NC4=CC=C(N5CCC(O)CC5)N=C4)N=C3N(C)C2)=C1)C6=CC=CC(C(F)(F)F)=C6

N-(3-(7-((6-(4-hydroxypiperidin-1-yl)pyridin-3-yl)amino)-1-methyl-1,4-dihydropyrimido[4,5-d]pyrimidin-3(2H)-yl)-4-methylphenyl)-3-(trifluoromethyl)benzamide

(-20℃)

With Ice Pack

≥ 2 years