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BMS-708163
CAS No. 1146699-66-2
BMS-708163 ( Avagacestat )
Catalog No. M10518 CAS No. 1146699-66-2
A potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 111 | In Stock |
|
| 10MG | 213 | In Stock |
|
| 25MG | 398 | In Stock |
|
| 50MG | 592 | In Stock |
|
| 100MG | 844 | In Stock |
|
| 500MG | 1701 | In Stock |
|
| 1G | Get Quote | In Stock |
|
Biological Information
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Product NameBMS-708163
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM.
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DescriptionA potent, selective and orally bioavailable inhibitor of γ-secretase with Aβ40 IC50 of 3.0 nM; demonstrates 193-fold selectivity against Notch; significantly reduced Aβ40 levels for sustained periods in brain, plasma, and cerebrospinal fluid in rats and dogs. Alzheimer's Disease Phase 2 Discontinued
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SynonymsAvagacestat
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PathwayWnt/Notch/Hedgehog
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Targetγ-secretase
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Recptorγsecretase(Aβ40);γsecretase(Aβ42)
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Research AreaNeurological Disease
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IndicationAlzheimer Disease
Chemical Information
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CAS Number1146699-66-2
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Formula Weight520.89
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Molecular FormulaC20H17ClF4N4O4S
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Purity>98% (HPLC)
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Solubility10 mM in DMSO
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SMILESO=C(N)[C@H](N(CC1=CC=C(C2=NOC=N2)C=C1F)S(=O)(C3=CC=C(Cl)C=C3)=O)CCC(F)(F)F
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Chemical NamePentanamide, 2-[[(4-chlorophenyl)sulfonyl][[2-fluoro-4-(1,2,4-oxadiazol-3-yl)phenyl]methyl]amino]-5,5,5-trifluoro-, (2R)-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Gillman KW, et al. ACS Med Chem Lett. 2010 Mar 22;1(3):120-4.
2. Albright CF, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):686-95.
3. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.
2. Albright CF, et al. J Pharmacol Exp Ther. 2013 Mar;344(3):686-95.
3. Mitani Y, et al. J Neurosci. 2012 Feb 8;32(6):2037-50.
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