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Home - Products - Cell Cycle/DNA Damage - HDAC - OBP-801

OBP-801

CAS No. 328548-11-4

OBP-801 ( OBP801;YM 753;Spiruchostatin A )

Catalog No. M14075 CAS No. 328548-11-4

OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    OBP-801
  • Note
    Research use only, not for human use.
  • Brief Description
    OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM.
  • Description
    OBP-801 (YM 753;Spiruchostatin A) is a novel cyclic-peptide-based HDAC inhibitor with IC50 of 2 nM; significantly inhibits the cell growth on comparison with each agent alone and synergistically increased apoptosis with the induction of Bim; significantly suppresses tumor growth in vivo.Kidney Cancer Phase 1 Clinical
  • Synonyms
    OBP801;YM 753;Spiruchostatin A
  • Pathway
    Cell Cycle/DNA Damage
  • Target
    HDAC
  • Recptor
    HDAC
  • Research Area
    Cancer
  • Indication
    Kidney Cancer

Chemical Information

  • CAS Number
    328548-11-4
  • Formula Weight
    473.60
  • Molecular Formula
    C20H31N3O6S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    O=C1C[C@H](O2)/C=C/CCSSC[C@@H](NC([C@@H](C)N1)=O)C(N[C@H](C(C)C)[C@@H](O)CC2=O)=O
  • Chemical Name
    (1S,5S,6R,9S,20R,E)-5-hydroxy-6-isopropyl-20-methyl-2-oxa-11,12-dithia-7,19,22-triazabicyclo[7.7.6]docos-15-ene-3,8,18,21-tetraone

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Shindoh N, et al. Int J Oncol. 2008 Mar;32(3):545-55.
2. Yoshioka T, et al. Gynecol Oncol. 2013 May;129(2):425-32.
3. Furutani A, et al. Oncol Res. 2014;21(5):281-6.
4. Akiyama M, et al. Oncol Res. 2017 Sep 21;25(8):1245-1252.
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