RTS-V5 ( Dual HDAC-proteasome inhibitor RTS-V5 )

Catalog No. M13629 CAS No. 2285346-31-6

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Datasheet

HNMR

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Product Name

RTS-V5
Note

Research use only, not for human use.
Brief Description

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor.
Description

RTS-V5 (Dual HDAC-proteasome inhibitor RTS-V5) is the first-in-class, dual HDAC-proteasome inhibitor with IC50 of 0.27 uM (HDAC6), inhibits HDAC8 (IC50=0.53 uM), and low activity against HDAC/1/2/3; demonstrates cytotoxicity against leukemia and multiple myeloma cell lines as well as therapy-refractory primary patient-derived leukemia cells.
Synonyms

Dual HDAC-proteasome inhibitor RTS-V5
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

2285346-31-6
Formula Weight

525.61
Molecular Formula

C27H35N5O6
Purity

>98% (HPLC)
Solubility

——
SMILES

O=C(N[C@@H](CC(NCC(C)(C)C)=O)C(N[C@@H](C)C(NCC1=CC=CC=C1)=O)=O)C2=CC=C(C(NO)=O)C=C2
Chemical Name

N1-((S)-1-(((S)-1-(Benzylamino)-1-oxopropan-2-yl)amino)-4-(neopentylamino)-1,4- dioxobutan-2-yl)-N4 -hydroxyterephthalamide

1. Bhatia S, et al. J Med Chem. 2018 Oct 26. doi: 10.1021/acs.jmedchem.8b01487.

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