T247

Research use only, not for human use.

A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.

A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8; induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells; shows promising activity for anticancer and antiviral benefits; also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.

T 247;HDAC3 inhibitor T247

Cell Cycle/DNA Damage

HDAC

HDAC

——

——

1451042-18-4

389.48

C21H19N5OS

>98% (HPLC)

——

O=C(NC1=CC=CC=C1N)C2=CC=C(C3=CN(CCC4=CSC=C4)N=N3)C=C2

N-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide

(-20℃)

With Ice Pack

≥ 2 years