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T247
CAS No. 1451042-18-4
T247 ( T 247;HDAC3 inhibitor T247 )
Catalog No. M11944 CAS No. 1451042-18-4
A potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 50MG | 999 | Get Quote |
|
| 100MG | 1449 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameT247
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NoteResearch use only, not for human use.
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Brief DescriptionA potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8.
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DescriptionA potent and selective HDAC3 inhibitor with IC50 of 0.24 uM, >75-fold selectivity over HDAC1 and no activity against HDAC4/6/8; induces dose-dependent selective increase of NF-κB acetylation in human colon cancer HCT116 cells, induces growth inhibition of cancer cells, and activates HIV gene expression in latent HIV-infected cells; shows promising activity for anticancer and antiviral benefits; also decreases TMEM16A expression and functional activity in both prostatic cancer cell line PC-3 and the breast cancer cell line YMB-1.
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SynonymsT 247;HDAC3 inhibitor T247
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PathwayCell Cycle/DNA Damage
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TargetHDAC
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RecptorHDAC
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Research Area——
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Indication——
Chemical Information
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CAS Number1451042-18-4
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Formula Weight389.48
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Molecular FormulaC21H19N5OS
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Purity>98% (HPLC)
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Solubility——
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SMILESO=C(NC1=CC=CC=C1N)C2=CC=C(C3=CN(CCC4=CSC=C4)N=N3)C=C2
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Chemical NameN-(2-aminophenyl)-4-[1-(2-thiophen-3-ylethyl)-1H-[1],[2],[3]triazol-4-yl]benzamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Suzuki T, et al. PLoS One. 2013 Jul 16;8(7):e68669.
2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.
3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
2. Matsuba S, et al. J Pharmacol Exp Ther. 2014 Dec;351(3):510-8.
3. Methot JL, et al. Bioorg Med Chem Lett. 2008 Feb 1;18(3):973-8.
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