BRD4354( BRD 4354 )

Catalog No. M14024 CAS No. 315698-07-8

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

Group Booking Get Quotation Bulk Inquiry Add to Cart

Product Name

BRD4354
Note

Research use only, not for human use.
Brief Description

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM.
Description

BRD4354 is a moderately potent, selective, reversible inhibitor of HDAC5 and HDAC9 with IC50 of 0.85 uM and 1.88 uM; shows weak activity against HDACs 4, 6, 7, and 8 (IC50=3.88-13.8 uM) and no inhibitory effect on other class I HDACs 1, 2, and 3 (IC50 > 40 uM).
In Vitro

BRD 4354 is a moderately potent inhibitor of HDAC5 and HDAC9, with BRD4354 having half-maximum inhibitory concentrations (IC50) of 0.85 μM and 1.88 μM, respectively. BRD 4354 also inhibits HDACs 4, 6, 7, and 8 at higher concentrations (3.88-13.8 μM) but demonstrates less of an inhibitory effect on other class I HDACs 1, 2, and 3 (IC50>40 μM) .
In Vivo

——
Synonyms

BRD 4354
Pathway

Cell Cycle/DNA Damage
Target

HDAC
Recptor

HDAC
Research Area

——
Indication

——

CAS Number

315698-07-8
Formula Weight

382.892
Molecular Formula

C21H23ClN4O
Purity

>98% (HPLC)
Solubility

DMSO : 125 mg/mL326.46 mM;
SMILES

OC1=C2N=CC=CC2=C(Cl)C=C1C(N3CCN(CC)CC3)C4=CC=CN=C4
Chemical Name

5-chloro-7-((4-ethylpiperazin-1-yl)(pyridin-3-yl)methyl)quinolin-8-ol

1. Boskovic ZV, et al. ACS Chem Biol. 2016 Jul 15;11(7):1844-51.

Calculator

molnova catalog