NPD13668
CAS No. 864819-54-5
NPD13668 ( NPD-13668;NPD 13668 )
Catalog No. M16274 CAS No. 864819-54-5
NPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NameNPD13668
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NoteResearch use only, not for human use.
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Brief DescriptionNPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels.
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DescriptionNPD13668 (NPD-13668) is a chemical novel modulator of EZH2-mediated gene silencing, inhibits EZH2/PCR2 activity and decreases H3K27me3 levels; reactivates the expression of silenced H3K27me3 target genes together with depletion of the H3K27me3 modification; effectively suppressed the cell growth of solid tumors even without EZH2 active mutations; inhibits cell proliferation in many cancer cells (PC3 cell IC50=5.39 uM); NPD13668 is a potential modulator of EZH2 methyltransferase activity.
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SynonymsNPD-13668;NPD 13668
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number864819-54-5
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Formula Weight392.41
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Molecular FormulaC22H20N2O5
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Purity>98% (HPLC)
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Solubility——
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SMILESCC1=C(C(=O)OC2=C1C=CC(=C2O)O)CC(=O)NCCC3=CNC4=CC=CC=C43
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Chemical NameN-(2-(1H-indol-3-yl)ethyl)-2-(7,8-dihydroxy-4-methyl-2-oxo-2H-chromen-3-yl)acetamide
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Murashima A, et al. J Biochem. 2019 Jan 25. doi: 10.1093/jb/mvz007.
molnova catalog
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