EPZ5676 ( EPZ5676; EPZ-5676; EPZ 5676; Pinometostat )

Catalog No. M11570 CAS No. 1380288-87-8

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

EPZ5676
Note

Research use only, not for human use.
Brief Description

EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM.
Description

EPZ-5676 is an S-adenosyl methionine (SAM) competitive inhibitor of protein methyltransferase DOT1L with Ki of 80 pM, demonstrating >37,000-fold selectivity against all other PMTs tested, inhibits H3K79 methylation in tumor. Phase 1.
Synonyms

EPZ5676; EPZ-5676; EPZ 5676; Pinometostat
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

DOT1L
Research Area

Cancer
Indication

——

CAS Number

1380288-87-8
Formula Weight

562.71
Molecular Formula

C30H42N8O3
Purity

>98%(HPLC)
Solubility

Ethanol: 92 mg/mL warmed (163.49 mM); DMSO: 100 mg/mL warmed (177.71 mM)
SMILES

O[C@H]1[C@H](N2C=NC3=C(N)N=CN=C23)O[C@H](CN([C@H]4C[C@@H](CCC5=NC6=CC(C(C)(C)C)=CC=C6N5)C4)C(C)C)[C@H]1O
Chemical Name

(2R,3R,4S,5R)-2-(6-amino-9H-purin-9-yl)-5-((((1r,3S)-3-(2-(5-(tert-butyl)-1H-benzo[d]imidazol-2-yl)ethyl)cyclobutyl)(isopropyl)amino)methyl)tetrahydrofuran-3,4-diol

1.Robert A. Protein methyltransferases in Y. AACR Annual Meeting, 2013.

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