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EPZ-031686
CAS No. 1808011-22-4
EPZ-031686( EPZ031686 | EPZ 031686 )
Catalog No. M12763 CAS No. 1808011-22-4
A potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM; Cell IC50= 36 nM).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 2MG | 192 | Get Quote |
|
| 5MG | 312 | Get Quote |
|
| 10MG | 447 | Get Quote |
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| 25MG | 714 | Get Quote |
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| 50MG | 1017 | Get Quote |
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| 100MG | 1368 | Get Quote |
|
| 200MG | Get Quote | Get Quote |
|
| 500MG | Get Quote | Get Quote |
|
| 1G | Get Quote | Get Quote |
|
Biological Information
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Product NameEPZ-031686
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NoteResearch use only, not for human use.
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Brief DescriptionA potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM; Cell IC50= 36 nM).
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DescriptionA potent, selective, small molecule SMYD3 inhibitor (Biochem IC50=3 nM; Cell IC50= 36 nM); displays <30% inhibition against 16 histone methyltransferase targets at 10 uM; shows good oral bioavailability and more favorable ADME profile than EPZ030456; orally active.
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In Vitro——
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In Vivo——
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SynonymsEPZ031686 | EPZ 031686
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research AreaCancer
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Indication——
Chemical Information
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CAS Number1808011-22-4
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Formula Weight591.0858
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Molecular FormulaC26H34ClF3N4O4S
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Purity>98% (HPLC)
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SolubilityDMSO: ≥ 5.9 mg/mL
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SMILESO=C(C1=CC2=C(NC(C2)=O)C=C1Cl)N[C@H]3C[C@@](N4S(=O)(CC5CCN(CCCC(F)(F)F)CC5)=O)([H])CC[C@@]4([H])C3
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Chemical Name1H-Indole-5-carboxamide, 6-chloro-2,3-dihydro-2-oxo-N-[(3-endo)-8-[[[1-(4,4,4-trifluorobutyl)-4-piperidinyl]methyl]sulfonyl]-8-azabicyclo[3.2.1]oct-3-yl]-
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Mitchell LH, et al. ACS Med Chem Lett. 2015 Aug 27;7(2):134-8.
2. Rajajeyabalachandran G, et al. Expert Opin Ther Targets. 2017 Feb;21(2):145-157.
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