BCI-121 ( BCI 121;BCI121 )

Catalog No. M14473 CAS No. 432529-82-3

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

BCI-121
Note

Research use only, not for human use.
Brief Description

BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor.
Description

BCI-121 (BCI121) is a substrate-competitive SMYD3 inhibitor that significantly inhibits SMYD3-substrate interaction and chromatin recruitment and is effective in reducing proliferation in various cancer cells types; impairs SMYD3-mediated H4 in vitro methylation, reduced proliferation of HT29 and HCT116 cells; reproduces the effects of SMYD3-targeted RNAi.
Synonyms

BCI 121;BCI121
Pathway

Chromatin/Epigenetic
Target

HMTase
Recptor

SMYD3
Research Area

——
Indication

——

CAS Number

432529-82-3
Formula Weight

340.22
Molecular Formula

C14H18BrN3O2
Purity

>98% (HPLC)
Solubility

DMSO: 100 mg/mL, 293.93 mM （ < 1 mg/ml refers to the product slightly soluble or insoluble )
SMILES

O=C(NC1=CC=C(Br)C=C1)CN2CCC(C(N)=O)CC2
Chemical Name

4-(Aminocarbonyl)-N-(4-bromophenyl)-1-piperidineacetamide

1. Peserico A, et al. J Cell Physiol. 2015 Oct;230(10):2447-2460.
2. Huang L, et al. Am J Transl Res. 2017 Jan 15;9(1):1-14.

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